Catabasis Pharmaceuticals Announces Upcoming Presentation on CAT-5571 as a Potential Treatment for Cystic Fibrosis at the 31st Annual North American Cystic Fibrosis Conference
-- CAT-5571 is a Host-Directed Therapy in Development to Treat Cystic Fibrosis-Associated Respiratory Infections --
A poster titled “CAT-5571 Improves the Clearance of Intracellular Burkholderia
Cenocepacia from Primary Cystic Fibrosis Macrophages,” resulting
from a collaboration between Catabasis and Dr.
CAT-5571 is an investigational oral small molecule that is being developed as a potential host-directed therapy for cystic fibrosis (CF)-associated respiratory infections. CAT-5571 restores host defense by activating autophagy, a mechanism for recycling cellular components and digesting pathogens. Autophagy is depressed in CF, and by restoring autophagy, CAT-5571 reestablishes host defense to enhance the clearance of pathogens, including Pseudomonasaeruginosa and Burkholderia cenocepacia, in preclinical models of CF. People with CF suffer from persistent lung infections with opportunistic pathogens such as P. aeruginosa and B. cenocepacia, causing chronic infections that are difficult to eradicate and lead to respiratory failure. CAT-5571 has the potential to augment the efficacy of antibiotics and could also be used with other CF therapies, including transmembrane conductance receptor (CFTR) targeted agents.
About Cystic Fibrosis
Cystic fibrosis (CF) is a rare, chronic, genetic, life-shortening disease that affects over 70,000 people with CF worldwide. In CF, a malfunctioning cystic fibrosis transmembrane conductance regulator ion channel impairs chloride secretion, resulting in deficient host defense mechanisms and deleterious effects on multiple organs, particularly the lung. Over time, people with CF develop chronic lung infections caused by multiple bacteria, including most frequently P. aeruginosa. Cardiorespiratory failure caused by these persistent, difficult to treat lung infections remains the primary cause of death in people with CF. Chronic bacterial infection in the lungs of people with CF represents a significant unmet medical need that is not adequately addressed with current therapies.
Investor and Media Contact
Catabasis Pharmaceuticals, Inc.
Andrea Matthews, 617-349-1971